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12 October 2021 This was a public lecture, the first of the UCL Faculty of Medical Sciences lecture series, 2021. It is also available on the UCL FMS YouTube channel at • 'One-shot' radiotherapy safer and as effec... Improving breast cancer treatment: Long-term results of the TARGIT-A randomised trial (www.targit.org.uk) of risk-adapted single-dose TARGIT-IORT given during lumpectomy for breast cancer vs whole breast radiotherapy given post-operatively by visiting the radiotherapy centre daily for 3 to 6 weeks. Selected recent scientific papers and talks 1) The BMJ paper is available at https://www.bmj.com/content/370/bmj.m... The accompanying opinion piece is at https://blogs.bmj.com/bmj/2020/08/19/... UCL video is at • TARGIT-IORT during surgery is better for p... BMJ academic video is at • Single dose radiotherapy for women with ea... 2) Further analysis paper published in the British Journal of Cancer can be accessed at https://www.nature.com/articles/s4141... and an invited blog post about it is here https://go.nature.com/3ymrplc and a short video is at • New insights from the TARGIT A trial 2021 3) Comparison of 'no-radiotherapy' trials, compressed whole breast radiotherapy trials and other partial breast irradiation randomised trial is published in Nature Reviews Clinical Oncology at https://static-content.springer.com/e... as part of the article https://www.nature.com/articles/s4157... and in the British Journal of Cancer https://www.nature.com/articles/s4141... 4) Worldwide adoption is described in this UCL Discovery preprint http://doi.org/10.14324/000.wp.10121050 5) How TARGIT-IORT is very different from ELIOT https://www.thelancet.com/journals/la... 6) How TARGIT-IORT is better for patients than other Partial Breast Irradiation (PBI) approaches https://www.redjournal.org/article/S0... Slide credit - Jayant S Vaidya and Uma J Vaidya