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In this video, I summarize the 4 tips for achieving Metabolic Flexibility According to Georgi Dinkov's Definition of what it means to be Metabolically Flexible. 🔔 SUBSCRIBE / @agereversingdoc 🧬🔥 Let’s transform your health and reignite the purpose you were meant to live with. Get in touch with me today. https://drjoelrosen.com/get-in-touch/ ⚕️🥼to end your exhaustion and burnout? Now’s Your Chance To Work One-on-One With Joel https://bit.ly/workwithDRJOEL Free Access]:💪 The Age-Reversing Blueprint User’s Guide Embark on your personalized Age-Reversing journey today https://www.agereversingblueprint.com... If you are looking to find out how old you are using the world's most accurate biological age test, now’s your chance to learn how fast (or slow) you are aging, https://bit.ly/biologicalagetest What does it mean to be Metabolic flexible? The best example is a young, healthy child. Oxidize, which means turning the macronutrients from the food we eat into ATP, CO2, and H20 when releasing energy. The Macronutrients are made up of protein, carbohydrates, and fats; the body directly processes carbs into sugars, and dietary fat, while converting the protein we eat into sugars. They get tired much quicker, but they also recover much faster. Children process foods very quickly, they get hungry very quickly, When you don't provide them with glucose for a period of time, they get crankier, because they are switching over to burn (the oxidation) of fat. But the energy is still there. When you feed them they usually get sleeping, they easily recover, and they are up and at it again. That process degrades as age advances, which shows up as varying degrees of insulin resistance. Even if you haven't been diagnosed as a diabetic. Accumulation of extra fat, especially around the midsection, and inability to process properly glucose. However, a metabolically flexible child can handle the process effectively. They eat sugar, and experience the effects of insulin, but don't become resistant. Something shifting us towards insulin resistance. Enter In The Concept Of The Randle Cycle: On the very basis, there is a competition between glucose and free fatty acids, for oxidation, or being used as the primary fuel. They compete for co-factors and basically attention. When supplied with both fats and carbohydrates, it depends on the relative proportions and relative amounts for each. The level of metabolic flexibility varies from person to person. If the body is oxidizing fats, and the glucose amount is above what the cell can process, because the cell is preoccupied with burning fats, it has to go somewhere. Build up of these reduced equivalent, because the metabolic fire is already burning, The other pathway for glucose to go is to make (synthesize) fats. Need oxidized factors, NAD+, FAD+, NADP+ Emergency oxidant to accept the hydrogen electron, pyruvate is used Pyruvate then converts into Lactate A subset of people can process fatty acids perfectly fine, but when you give them too much sugar to process, they lose their metabolic flexibility and become insulin-resistant. What is happening here? Oversupply of fatty acids, cannot metabolize glucose effectively. MUST REIGN THAT IN TO FIX THAT. Must lower the oversupply of fatty acids and lipolysis (the burning of it) In young kids, eating sugar/glucose after a long bout of fasting, or burning fat, will lower lipolysis, because insulin is released, as children are STILL METABOLICALLY FLEXIBLE Because insulin is ANTI LIPOLYTIC (against fat burning), and because kids are metabolically flexible, the fat burning is turned off, and the glucose that the kid just ate, is able to be prioritized and burnt. That should happen as we get older, but doesn't, and is called = INSULIN RESISTANCE When NOT metabolically flexible, you will not lower lipolysis by eating and having to burn glucose, Therefore glucose and insulin can be constantly elevated, Cannot switch over to burning glucose like young children are, Metabolically inflexibility, Limit oversupply of fat, to the cell or limit their oxidation, fatty acid inhibitors, or beta-oxidation inhibitors, beta-blockers, When you do that, studies show that cells revert back to burning glucose, Giving the cell a break by limiting the oversupply of fat. Oversupply of fat, and for as long as that is happening you will remain metabolically inflexible. This leads to the accumulation of fat, Combine that with Stress, which causes chronic cortisol and adrenaline to be higher than optimal and the main role of adrenaline is to increase lipolysis, So Stress is associated with supply fat, Underlying problem, chronic stress, chronic inflammation Metabolic in origin and encouraging studies demonstrating that they are reversible Formula For Success: Typically equal ratios of Protein: Carbs: Fats, 33% of each Limit Seed oils/P FA's Mostly Saturated Fats, of animal origin