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Cataract a major form of blindness that occurs when the structure of crystallin proteins that make up the lens in our eyes deteriorates, causing damaged or disorganised proteins to aggregate and form a milky blue or brown layer, which ultimately affects lens transparency. Thus, prevention of the formation of these aggregates as well as their destruction in the early stage of disease progression is a major treatment strategy for cataracts, and materials that can carry out this task could make cataract prevention affordable and accessible. इंस्टीट्यूट आफ नैनो साइंस एंड टेक्नोलॉजी मोहाली के वैज्ञानिकों ने नैनो टेक्नोलॉजी का इस्तेमाल करके खास तरीके का फॉर्मूलेशन खोज निकाला है जिससे मोतियाबिंद को बगैर ऑपरेशन के खत्म किया जा सकता है आखिरकार यह खोज क्या है और कैसे यह मोतियाबिंद को खत्म करेगी इस बारे में जानने के लिए न्यूज़ स्टेशन के संपादक सिद्धार्थ ने INST की वैज्ञानिक Dr Jiban Jyoti Panda से खास बातचीत की A team of scientists from the Institute of Nano Science & Technology (INST) an autonomous institute under the Department of Science & Technology, Government of India has developed nanorods from the nonsteroidal anti-inflammatory drug (NSAID) Aspirin, a popular medication used to reduce pain, fever, or inflammation and found it to be an effective non–invasive small molecule-based nanotherapeutics against cataract. Their research published in the Journal of Materials Chemistry B could help prevent cataracts in an economical and less complicated way. They have used the anti-aggregation ability of self-build aspirin nanorods as an effective non –invasive small molecule-based nanotherapeutics against cataract. Aspirin nanorods prevent the aggregation of crystallin protein and various peptides derived from its fragmentation, which play a crucial role in cataract formation. They prevent the protein/peptide aggregation through bio-molecular interactions, which convert beta-turn like the structure of the crystallin peptides, responsible for amyloid formation into coils and helices, those fail to aggregate. These were found to prevent cataract formation by inhibiting aggregation of crystallin, and crystallin derived peptide aggregates. As with aging and under various conditions, the lens protein crystallin aggregates to form opaque structures in the eye lens, which impairs vision and cause cataract. #InstituteNanoScienceTechnology #NonsurgicalPreventionCataract #DrJibanJyotiPanda #TellMeDoctor