What Your TRIGLYCERIDE Levels Mean | New Trial скачать в хорошем качестве

What Your TRIGLYCERIDE Levels Mean | New Trial

Triglycerides are often misunderstood. We look at new evidence on triglyceride lowering and heart disease. An overview of the value and caveats of trigliceryde levels New trial on triglyceride lowering. triglyceride-lowering drug vs placebo. participants: high triglycerides, low HDL-cholesterol. LDL-cholesterol was low, only triglycerides were high fibrate reduced triglycerides. HDL-cholesterol went up by 5% no significant change in risk of cardiovascular events (heart attack, stroke or death). why wasn’t risk lower if triglycerides came down? Lipids like triglycerides and cholesterol are carried in our bloodstream in lipoproteins like LDL and VLDL. VLDLs carry mostly triglycerides, LDLs carry mostly cholesterol. in cardiovascular research risk follows number of lipoproteins, not lipid level. so cholesterol and triglycerides are markers usually the higher the cholesterol and triglycerides, the more lipoproteins. VLDLs and LDLs are cousins. VLDLs can turn into LDLs. both carry ApoB the fibrate didn't reduce apoB so risk didnt go down, regardless of what happens to triglycerides or cholesterol. fibrates lower VLDLs (which carry mostly TGs). So both triglycerides and their carriers go down. But it raises large LDLs VLDLs were reduced by being converted into LDLs. Reducing triglycerides by transforming one ApoB lipoprotein, VLDLs, into another, LDLs, is not helpful Other trials: lowering triglycerides without lowering apoB doesnt help genetics: triglyceride levels have little if any effect on cardiovascular risk when we account for ApoB raising HDL-cholesterol doesn´t help; triglycerides and HDL-cholesterol combined play small if any role in cardiovascular risk accounting for apoB; people with good triglycerides and HDL-cholesterol can still have plaque in their arteries triglycerides associate with risk at population level; higher triglycerides associate with higher risk; lowering them doesn’t necessarily lower risk high triglycerides reflect overweight, diabetes etc. changing triglycerides directly doesnt necessarily do much markers vs makers. triglycerides, HDL-cholesterol (tracks well with risk but changing HDL-c directly makes little difference), LDL-cholesterol triglycerides/HDL-cholesterol, total cholesterol/HDL-cholesterol, reflect obesity, diabetes but higher HDL-cholesterol genetically doesn´t affect risk triglycerides can come down without change to apoB high triglycerides: chances are i´m overweight or diabetic; if triglycerides come down due to weight loss, they reflect positive change very high triglycerides can be bad news besides heart disease. pancreatitis and fatty liver. don´t ignore high triglycerides. but don’t assume lower triglycerides mean lower heart disease risk; also can’t assume low triglycerides mean safety. could still have determinants of cardiovascular risk out of whack, like high blood pressure or high ApoB fibrates reduce triglycerides and VLDLs yet risk wasn´t lower Connect with me: Facebook:   / drgilcarvalho   Twitter:   / nutritionmades3   Animations: Even Topland @toplandmedia References: 1-https://www.nejm.org/doi/full/10.1056... 2-https://jamanetwork.com/journals/jama... 3-https://jamanetwork.com/journals/jama... 4-https://jamanetwork.com/journals/jama... 5-https://www.nejm.org/doi/full/10.1056... 6-https://pubmed.ncbi.nlm.nih.gov/33870... 7-https://link.springer.com/book/10.100... 8-https://elifesciences.org/articles/58... 9-https://www.ahajournals.org/doi/full/... 10-https://jamanetwork.com/journals/jama... 11-https://journals.plos.org/plosmedicin... 12-https://www.ncbi.nlm.nih.gov/pmc/arti... 13-https://academic.oup.com/ije/article/... 14-https://www.sciencedirect.com/science... 15-https://academic.oup.com/eurheartj/ar... 16-https://academic.oup.com/eurheartj/ar... Disclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!. #NutritionMadeSimple #GilCarvalho 0:00 New trial on Triglyceride lowering 1:21 Triglycerides vs Lipoproteins 3:55 Conclusion of the trial 5:24 LDL particle size 6:30 Big picture 7:50 Markers vs Makers 10:27 Ratios 11:36 Value of Triglycerides 13:02 Improving health as a whole