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Marcello Maida on "The role of generative language systems in increasing patient awareness of colon cancer screening" Answers generated by ChatGPT to questions on colorectal cancer (CRC) screening were rated by 20 gastroenterology experts, 20 nonexperts, and 100 patients. Experts rated the overall accuracy (scale 1–6) as 4.8, and completeness and comprehensibility (scales 1–3) as 2.1 and 2.8, respectively. Patients rated the responses as complete, comprehensible, and trustable in 97% to 100% of cases. Nonetheless, these results must be interpreted with caution as they refer to a specific setting and cannot be generalized to overall ChatGPT performance. Find the article at: https://doi.org/10.1055/a-2388-6084 Marcello Maida, Daryl Ramai, Yuichi Mori et al. The role of generative language systems in increasing patient awareness of colon cancer screening Endoscopy 2025; 57: 262–268 DOI 10.1055/a-2388-6084 ISSN 0013-726X © 2024. Thieme. All rights reserved. Georg Thieme Verlag KG, Rüdigerstraße 14, 70469 Stuttgart, Germany