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After we learned how to diagnose CHF, now it's time for treatment. So let's start with prescribing optimal medications for a patient with HFrEF. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure https://www.escardio.org/Guidelines/C... PARADIGM-HF trial, Angiotensin–Neprilysin Inhibition versus Enalapril in Heart Failure https://www.nejm.org/doi/full/10.1056... TRANSITION Study, NT-proBNP Response to Sacubitril/Valsartan in Hospitalized Heart Failure Patients With Reduced Ejection Fraction. https://www.jacc.org/doi/abs/10.1016/... EMPEROR-Reduced trial, Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure https://www.nejm.org/doi/full/10.1056... DAPA-HF trial, Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction https://www.nejm.org/doi/full/10.1056... CHARM-Alternative trial, Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function intolerant to angiotensin-converting-enzyme inhibitors https://www.thelancet.com/journals/la... Val-HeFT trial, A Randomized Trial of the Angiotensin-Receptor Blocker Valsartan in Chronic Heart Failure https://www.nejm.org/doi/full/10.1056... SHIFT trial, Ivabradine and outcomes in chronic heart failure. A randomised placebo-controlled study https://www.thelancet.com/journals/la... VICTORIA trial, Vericiguat in Patients with Heart Failure and Reduced Ejection Fraction https://www.nejm.org/doi/full/10.1056... GALACTIC-HF trial, Cardiac Myosin Activation with Omecamtiv Mecarbil in Systolic Heart Failure https://www.nejm.org/doi/full/10.1056...