Gastrointestinal | Bile Synthesis скачать в хорошем качестве

Gastrointestinal | Bile Synthesis

Official Ninja Nerd Website: https://ninjanerd.org Ninja Nerds! In this lecture, Professor Zach Murphy will discuss the process of bile synthesis, focusing on the liver’s role in producing this vital digestive fluid. We begin by examining how hepatocytes convert cholesterol into primary bile acids—cholic acid and chenodeoxycholic acid—through a series of enzymatic steps, with cholesterol 7α-hydroxylase as the rate-limiting enzyme. These primary bile acids are then conjugated with glycine or taurine to form bile salts, increasing their solubility and effectiveness in emulsifying dietary fats. We then explore the composition of bile, which includes bile salts, phospholipids (mainly phosphatidylcholine), cholesterol, bilirubin, and electrolytes. The lecture details how bile is secreted into canaliculi, transported through the biliary tree, and stored in the gallbladder for release into the duodenum in response to cholecystokinin (CCK). Finally, we tie bile synthesis to the enterohepatic circulation, highlighting how bile salts are reabsorbed in the terminal ileum and recycled back to the liver, conserving resources and maintaining lipid digestion efficiency. We also briefly touch on the clinical importance of bile synthesis in conditions such as cholestasis, gallstones, and malabsorption syndromes. Enjoy the lecture and support us below! 🌐 Official Links Website: https://www.ninjanerd.org Podcast: https://podcast.ninjanerd.org Store: https://merch.ninjanerd.org 📱 Social Media   / ninjanerdlectures     / ninjanerdlectures     / ninjanerdlectures   https://x.com/ninjanerdsci/   / ninja-nerd   💬 Join Our Community Discord:   / discord   #ninjanerd #BileSynthesis #Gastrointestinal