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Donate to PCRI: https://pcri.org/donate For more information. visit www.pcri.org 0:12 Building Blocks for Treatment Plan 0:42 Who is the lecture for? 0:51 Advanced Cancer outside the Prostate 1:03 What is the problem? 1:27 Oversimplification? 1:49 Too many diagnostic options? 1:59 Multiplicity of practice and business models? 2:24 Misunderstood terms and concepts? 2:40 Outdated perceptions? 3:04 Too much information 3:30 Goals of this presentation 4:02 The Basics of Advanced Prostate Cancer 6:13 "Updated" Biology of Advanced Prostate Cancer 6:38 "Clonal" theory of Cancer 6:45 The Heterogeneity of Prostate Cancer Cells 10:20 Systemic treatments as of 2023 10:48 What is a systemic therapy? 11:28 Suppressive therapies 13:05 Cytotoxic therapies 14:12 Mechanism of Action (MOA) 14:52 Testosterone promotes prostate cancer growth 16:01 GnRH Hormone Therapy 16:27 Anti-Androgen Hormone Therapy 16:58 Hormone (Castrate) Resistant Prostate Cancer 17:28 ARPI Hormone Therapy 18:55 Chemotherapy 19:55 Immunotherapy 20:37 Radioligand Therapy 21:40 What's the best way to create a treatment plan? 25:03 Abbreviations pertaining to forms of therapy 25:46 Case study: Newly diagnosed Advanced Prostate Cancer 27:39 Triple therapy 28:51 What if you didn't start with Triple Therapy? 29:48 Case 1: Failing HT? 32:51 Chemotherapy first 34:12 Case 2: Failing HT + ARPI? 38:50 Less differentiated = more aggressive cancer = LESS PSA & PSMA 39:36 PSA Zero 40:24 Case 3: Failing HT + prior CHtx? 42:19 Case 4: Failing HT + ARPI + prior CHtx? 45:35 Proper "care and feeding" of your treatment plan 46:00 Regular and comprehensive follow up is key 47:13 Prior genetic testing 49:36 Updating genetic testing 50:43 Mutations relevant to PARPi 52:13 Mutations relevant to immunotherapy 54:07 Mutations relevant to PARPi or immunotherapy 57:05 Regular and comprehensive follow summary 57:24 Direct treatments as of 2023 58:15 DIY Combat Manual for Beating Prostate Cancer Videos 59:02 Multiple ways that residual disease can be eliminated 59:21 Chest surgery example 59:47 Radiation therapy example 1:01:25 Minimal invasive procedures 1:02:33 Misunderstood concepts 1:03:18 Stand-of-Care 1:05:11 Guidlines 1:05:58 Clinical trials 1:09:43 Oversimplified view of disease 1:10:08 List to bring to with you to physician meetings 1:10:48 Dr. Kwon's Team Don't know your stage? Take the quiz: visit http://www.prostatecancerstaging.org To learn more about prostate cancer, visit http://www.pcri.org Sign up for our newsletter here to receive the latest updates on prostate cancer and the PCRI: https://pcri.org/join Who we are: The Prostate Cancer Research Institute (PCRI) is a 501(c)(3) not-for-profit organization that is dedicated to helping you research your treatment options. We understand that you have many questions, and we can help you find the answers that are specific to your case. All of our resources are designed by a multidisciplinary team of advocates and expert physicians, for patients. We believe that by educating yourself about the disease, you will have more productive interactions with your medical professionals and receive better-individualized care. Feel free to explore our website at pcri.org or contact our free helpline with any questions that you have at pcri.org/helpline. Our Federal Tax ID # is 95-4617875 and qualifies for maximum charitable gift deductions by individual donors.