GPCRs and the Science Behind Pain & Recovery with Dr. Alex Serafini / Dr. GPCR Podcast скачать в хорошем качестве

GPCRs and the Science Behind Pain & Recovery with Dr. Alex Serafini / Dr. GPCR Podcast

From Chronic Pain to GPCR Discovery: Dr. Alex Serafini’s Unconventional Path in Science What happens when a personal health crisis becomes the catalyst for a career in research? In this episode, we dive into the story of Dr. Alex Serafini, an MD-PhD researcher whose work on RGS proteins, GPCR signaling, and pain neuroscience is helping reshape the future of chronic pain therapy. Dr. Serafini shares how his early experience with untreated pain led him to explore the neurobiology of pain, the limitations of current treatments, and how GPCR targets and RGS proteins like RGS4 may offer a new way forward. We explore the role of in vivo models, transgenerational epigenetics, and how inflammation, sex, and the brain’s wiring intersect in complex pain states. This conversation also highlights the power of patient-first research, cross-disciplinary training, and building your career by thinking differently. Whether you're part of the GPCR research community, developing new therapeutics, or training to become a physician-scientist, this episode delivers key insights on how innovation happens at the intersection of science, strategy, and storytelling. ⏱️ Timestamps 0:00 – Intro & Serafini’s personal pain story 4:10 – From finance to FlexMed to MD-PhD 12:50 – Why RGS proteins matter in pain 20:15 – COVID, chronic pain & DRG surprises 35:00 – The reality of running a lab 47:00 – Advice for the next generation Subscribe for more real stories from the GPCR research community. Like and comment with your biggest takeaway. _____ Join Terry’s Corner today! Visit https://www.terrykenakin.com/ for expert-led, on-demand pharmacology courses, and join us in the upcoming AMAs with Dr. Terry Kenakin. _____ Visit Celtarys' website in the Ecosystem: https://www.ecosystem.drgpcr.com/celt... Read the DrGPCR x Celtarys Partnership Press Release: https://www.ecosystem.drgpcr.com/post... Learn more about Celtarys Research: https://www.celtarys.com/ ______ Dr. GPCR is dedicated to fostering a collaborative ecosystem focused on GPCRs. By connecting researchers, sharing knowledge, and facilitating partnerships, the #DrGPCR Ecosystem provides resources to support advancements in GPCR drug discovery. The ecosystem includes a variety of initiatives designed to inform and engage the scientific community, from courses and news updates to networking opportunities. 🧭 Links & Resources • Dr. GPCR Ecosystem: https://www.ecosystem.drgpcr.com/ • Dr. GPCR University Courses: https://www.ecosystem.drgpcr.com/gpcr... • Membership & Pricing: https://www.ecosystem.drgpcr.com/univ... • GPCR Weekly News: https://www.ecosystem.drgpcr.com/gpcr... #GPCRresearch #chronicpain #RGSproteins #GPCRpodcast #neuroscience