Neurocon 23--Emma Acerbo Ph. D. скачать в хорошем качестве

Neurocon 23--Emma Acerbo Ph. D.

Dr Emma Acerbo is a postdoctoral fellow at Emory University, having joined the institution in 2023 after completing her Ph.D. in neurosciences. Her research focuses on the fascinating realm of neurostimulation within the context of epilepsy. During her doctoral studies, she delved into the profound effects of neurostimulation, specifically exploring a groundbreaking non-invasive technique known as "temporal interference." This innovative approach has the potential to revolutionize deep brain stimulation. She applied this novel method in mouse models of epilepsy, subsequently scaling it up for human application through stimulation in human cadavers. Her current work involves the exciting challenge of implementing this cutting-edge technique in epileptic patients who are implanted with stereoelectroencephalography (SEEG) electrodes. Her research journey continues as she strives to make advancements in the field of epilepsy management and neurostimulation." Presentatio: Non-invasive temporal interference electrical stimulation of the human hippocampus Abstract: Deep brain stimulation (DBS) via implanted electrodes is used worldwide to treat patients with severe neurological and psychiatric disorders. However, its invasiveness precludes widespread clinical use and deployment in research. Temporal interference (TI) is a strategy for non-invasive steerable DBS using multiple kHz-range electric fields with a difference frequency within the range of neural activity. Here we report the validation of the non-invasive DBS concept in humans. We used electric field modeling and measurements in a human cadaver to verify that the locus of the transcranial TI stimulation can be steerably focused in the hippocampus with minimal exposure to the overlying cortex. We then used functional magnetic resonance imaging and behavioral experiments to show that TI stimulation can focally modulate hippocampal activity and enhance the accuracy of episodic memories in healthy humans. Our results demonstrate targeted, non-invasive electrical stimulation of deep structures in the human brain.