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Cervical Intraepithelial Neoplasia (CIN) is a precancerous condition where abnormal cells grow on the surface of the cervix. It’s most often caused by persistent infection with high-risk types of Human Papillomavirus (HPV)—especially HPV-16 and HPV-182. 🧬 CIN Classification Grade Description Cancer Risk CIN 1 Mild dysplasia; abnormal cells in lower 1/3 of epithelium Low—often resolves naturally CIN 2 Moderate dysplasia; abnormal cells in 1/3 to 2/3 of epithelium Moderate—may need treatment CIN 3 Severe dysplasia; abnormal cells in more than 2/3 of epithelium High—considered carcinoma in situ2 ⚠️ Symptoms CIN usually has no symptoms, but may occasionally cause: Irregular vaginal bleeding Spotting after intercourse Unusual discharge Most cases are discovered during routine Pap smears or HPV testing3. 🩺 Diagnosis Pap smear: Detects abnormal cervical cells HPV test: Identifies high-risk virus strains Colposcopy: Magnified visual exam of cervix Biopsy: Confirms CIN grade and guides treatment3 🛠️ Treatment Options CIN Grade Management CIN 1 Often monitored—may regress naturally CIN 2–3 May require removal of abnormal cells via: LEEP (Loop Electrosurgical Excision Procedure) Cold knife cone biopsy Laser therapy or cryotherapy Hysterectomy (rare, for persistent or recurrent cases)3 | 🧠 Prevention & Outlook HPV vaccination (Gardasil, Cervarix) before sexual debut Regular cervical screening (Pap + HPV tests) Avoid smoking and practice safer sex With early detection and proper treatment, CIN has an excellent prognosis and rarely progresses to cervical cancer2. #CervicalIntraepithelialNeoplasia #CIN