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Metabolism-related fatty liver disease (MAFLD) is the most common form of chronic liver disease in the world. It is the general name of a series of liver diseases including steatosis, nonalcoholic steatohepatitis, cirrhosis and eventually hepatocellular carcinoma. At present, it is known that MAFLD is a complex systemic metabolic disease affected by multiple factors such as heredity and behavior habits, and involved in multiple pathways. Lipid ectopic deposition and insulin resistance are recognized as two major causes, but the specific pathogenesis is still unclear. At the 32nd annual meeting of the Asia-Pacific Association for Liver Research (APASL), this journal had the honor to interview Professor Luca Valenti of the University of Milan, Italy, and shared the molecular genetic characteristics and clinical application of MAFLD.