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Ronald P. Kaufman, Jr., MD, Professor of Urology, Albany Medical College, Albany, New York, reviews evidence comparing transrectal and transperineal prostate biopsies. In this 8-minute presentation, Dr. Kaufman highlights infection rates, cancer detection, and procedural considerations. Dr. Kaufman shares that while expert opinion has favored transperineal biopsy due to perceived lower infection rates, recent randomized trials challenge this view. Three key studies — ProBE-PC, PREVENT, and PERFECT — show comparable infection rates and cancer detection outcomes between the two approaches. He stresses that infection rates are consistently low across all studies, with no clear advantage for transperineal biopsy. Cancer detection rates are similar. Dr. Kaufman emphasizes that antibiotic prophylaxis is sufficient for transrectal biopsy, arguing that prolonged antibiotic use is unnecessary and poor stewardship. He stresses that both techniques are safe and effective when performed by skilled operators and that individual urologist expertise may influence outcomes more than the biopsy route itself. He advocates for improved training to enhance procedural consistency and safety, urging clinicians to base decisions on infection patterns, patient factors, and local expertise. Don't forget to join the GRU Community: https://grandroundsinurology.com/regi... Follow us on Twitter/X: https://x.com/GRUrology And like and subscribe to us here on YouTube!