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Differential diagnosis (Zhen Duan) is a central concept in traditional Chinese medicine (TCM) theory. In clinical practice it is the process of identifying the specific pattern of disharmony or imbalance that is causing a patient’s symptoms and determining the appropriate treatment. In TCM, the body is seen as a complex system of interconnected functions and processes that are in balance when the person is healthy. When there is an imbalance, the body experiences symptoms and signs that reflect the nature and severity of the disharmony. Differential diagnosis involves a thorough evaluation of the patient’s symptoms and signs, including their physical, emotional, and mental states, as well as their pulse and tongue. The TCM practitioner will consider the patient’s age, gender, constitution, and other factors that may be relevant to the diagnosis. The TCM practitioner will use this information to identify the pattern of disharmony and determine the appropriate treatment. This may include acupuncture, herbal medicine, dietary recommendations, and other therapies. Differential diagnosis is an integral part of the TCM clinical process, and it requires a deep understanding of TCM theory and a skilled and experienced practitioner to correctly diagnose and treat the patient.