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Wesley A. Mayer, MD, discusses the AUA guidelines for the medical management of kidney stones, also known as nephrolithiasis. There are 27 guidelines, fitting into the categories of evaluation, diet therapy, pharmacologic therapy, and follow-up. Dr. Mayer urges urologists to care for the whole patient, and to not just focus on the surgical issue. Nephrolithiasis is both a surgical and medical disease, making follow-up with these patients essential. For example, urologists can use a metabolic work-up to reduce the risk of future stone formation. Dr. Mayer concludes by reemphasizing that stone management often requires multiple modalities, including diet and medication, and by noting that for complex cases, urologists may want to consider referring patients to a dietician or other expert.