ALL the Mechanism of Drug Action | Pharmacodynamics | Principles of Drug Action | Enzymes, Receptors скачать в хорошем качестве

ALL the Mechanism of Drug Action | Pharmacodynamics | Principles of Drug Action | Enzymes, Receptors

📝 All videos on General Pharmacology: https://www.nonstopneuron.com/post/ge... 🌐 Explore our entire animation video library: https://www.nonstopneuron.com/ ● Follow me at: • Instagram:   / nonstopneuron   • Facebook:   / nonstopneuron   ALL the Mechanisms of Drug Action | Pharmacodynamics | Principles of Drug Action | Enzymes, Receptors: Pharmacodynamics is the study of what a drug does to the body. In this, we learn how the drugs produce their effects, what kind of effects do they produce, how much of an effect is produced, and how the effects are modified. The term effect refers to the type of response produced by the drug. And the term action refers to how the effect is produced. So the action comes before the effect. The same effect may be produced by multiple actions. So knowing only about the effect is not sufficient. We need to know the exact action as well. The most common targets for the drugs are functional proteins like enzymes, transport proteins, and receptors. But apart from them, they may act on other biomolecules as well. And some agents act by purely physical or chemical means. Enzyme stimulation by a truly foreign substance is very rare. But inhibition is very common. In competitive inhibition, the drug competes with the substrate for the same catalytic site. If the bond is weak, the inhibition can be reversed by increasing the concentration of substrate. But if the bond is a strong covalent bond, it cannot be reversed. In noncompetitive inhibition, the drug binds at a different site. Coming to the receptors, the ability of a drug to bind with a receptor is called affinity. And ability to trigger a response is called intrinsic activity. Agonist activates receptors to the maximum level. Partial agonist does it partially. antagonist does not cause any change. And inverse agonist stops constitutively active receptors. If the binding site on the receptor is the same, they all prevent the activity of each other. Overstimulation of receptors can cause desensitization. And prolonged inactivity can cause super sensitivity. Chapters: 00:00 Introduction to Pharmacodynamics 01:40 Action vs Effect 04:09 Target Molecules of Drugs 05:08 Enzyme Inhibition 12:40 Transport Proteins as Targets of Drugs 13:55 Physiology of Receptors 20:13 Drugs Actions on Receptors 25:44 Receptor Regulation 31:01 Other Biomolecules as Target of Drugs 31:39 Drug Actions by Physical or Chemical Mean 34:33 Summary 37:24 Bonus Points Dr Vipul Navadiya Nonstop Neuron Medical Animation Medical Animation Videos Physiology DISCLAIMER: This video is for education purposes only. Although every effort is made to ensure the accuracy of the material, viewers should refer to the appropriate regulatory body/authorized websites, guidelines, and other suitable sources of information as deemed relevant and applicable. In view of the possibility of human error or changes in medical science, any person or organization involved in the preparation of this work accepts no responsibility for any errors or omissions, or results obtained from the use of information in this video.