INTRACELLULAR ACCUMULATIONS: PIGMENTS скачать в хорошем качестве

INTRACELLULAR ACCUMULATIONS: PIGMENTS

A series of video tutorials discussing the topics for undergraduates in Pathology In this tutorial , i have discussed Intracellular accumulations- accumulation of PIGMENTS ***Follow me**** http://ilovepathology.com/ Twitter :   / vijaypatho     / ilovepathology2   Facebook:   / ilovepathology   Pigments are colored substances, some of which are normal constituents of cells (e.g., melanin), whereas others are abnormal and accumulate in cells only under special circumstances Exogenous Carbon / coal dust Anthracosis Coal workers pneumoconiosis Tattooing India ink, carbon Ingested Argyria : silver Lead ,carotenemia ENDOGENOUS Lipofuschin Melanin Hemosiderin LIPOFUSCHIN Insoluble pigment, also known as lipochrome or wear-and-tear pigment /aging pigment Derived from Latin Fuscus, Brown- Brown Lipid Composed of polymers of lipids and phospholipids in complex with protein Not injurious to the cell or its functions Telltale sign of free radical injury and lipid peroxidation Melanin (Greek. Melas-Black) Endogenous, non-hemoglobin-derived, brown-black pigment Only endogenous brown-black pigment Formed when the enzyme tyrosinase catalyzes the oxidation of tyrosine to dihydroxyphenylalanine in melanocytes and dendritic cells. Hemosiderin Hemoglobin-derived, golden yellow-to-brown, granular or crystalline pigment Major storage forms of iron Hemosiderin pigment represents aggregates of ferritin micelles Hemosiderin is ferric (+3 charge) iron Small amounts of hemosiderin can be seen in the mononuclear phagocytes of the bone marrow, spleen, and liver, which are actively engaged in red cell breakdown. ~-~~-~~~-~~-~ Please watch: "WARBURG EFFECT: Hallmark of CANCER. What, Why & How?"    • NEOPLASIA 6: WARBURG EFFECT: Hallmark...   ~-~~-~~~-~~-~