Скачать с ютуб Kerry Dearfield - Implementing a Founding Goal of EMGS: Mutagenicity Risk Assessment в хорошем качестве

Kerry Dearfield - Implementing a Founding Goal of EMGS: Mutagenicity Risk Assessment

Kerry Dearfield: Retired from EPA and USDA, Burke, VA, United States. Mutagenicity risk assessment, particularly focusing on heritable risk and germ-cell mutagenicity, is a founding goal of the Environmental Mutagenesis and Genomics Society (EMGS; founded as the Environmental Mutagen Society (EMS)). The early focus, as articulated in the first “position paper” from the society (Committee 17 publication), was with the genetic health of future generations, and therefore the main focus was upon germ line mutations. Many efforts, particularly via regulatory agencies and national and international bodies implemented this goal to ensure that mutagenicity risk assessment looking at genomic damage was part of the overall toxicity profile of a potential toxic substance. The U.S. Environmental Protection Agency, for example, published guidelines for mutagenicity risk assessment in addition to a testing strategy (“standard battery”) that is still a basis for much of regulatory testing today. Importantly, these approaches have germ-cell mutagenicity at their heart, though genomic damage in general can be detected. ICPEMC (affiliated with the International Association of Environmental Mutagen Societies (IAEMS)) provided a taskgroup report that describes a model for implementing quantitative genetic risk assessments for human populations. The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) provides for labelling provisions for substances known to induce heritable mutations or to be regarded as if they induce heritable mutations in the germ cells of humans. In looking forward, the use of newer technologies and quantitative modeling will continue to help implement this founding goal of the EMGS. Keywords: Inheritable mutation, Germline mutations, Germ-cell mutation