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Chronic anemia and transfusion-dependence are the main clinical challenges in LR-MDS, requiring more effective and durable treatment options. For the few therapies that are approved, tailoring treatment selection and optimizing management strategies are important to maximize outcomes for patients. Our expert faculty will explore the treatment landscape in LR-MDS, discuss how to navigate challenges associated with patient management whilst also analyzing the clinical evidence which shapes their treatment practice. This interactive session will allow direct engagement with experts and opportunities to share real-world challenges managing anemia for patients with LR-MDS. Welcome and Introductions: Unmet needs in lower-risk MDS Matteo Della Porta Navigating treatment considerations in an evolving landscape Amer Zeidan Maximizing the risk-benefit profile of novel therapies Thomas Cluzeau Panel discussion, Q&A and closing Amer Zeidan, Thomas Cluzeau, and Matteo Della Porta