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Musculoskeletal (MSK) modeling has become a powerful tool for noninvasive estimations of biomechanical loads, traditionally relying on marker-based motion capture systems in controlled laboratory settings. However, with advancements in wearable technology, inertial measurement units (IMUs) are emerging as a viable alternative for kinematic assessments. In this webinar, we will explore how MSK models can be leveraged for fracture risk prediction, integrating predicted ground reaction force (GRF) analyses and IMUs to improve clinical and research applications. We will discuss findings from our recent study evaluating spine forces using both IMU- and marker-based systems during various activities of daily living. This session will provide insights into: The role of MSK models in fracture prediction and load estimation The feasibility of IMUs for out-of-lab biomechanical assessments Future directions in noninvasive, scalable approaches to fracture risk assessment Presented by: Hugo Giambini, Ph.D. Assistant Professor, Department of Biomedical Engineering and Chemical Engineering Director, Musculoskeletal & Orthopedic Biomechanics Laboratory Adjunct Assistant Professor, Department of Orthopedics, University of Texas Health Science Center, San Antonio (UTHSCSA) The University of Texas at San Antonio (UTSA) (00:00) Introduction to the AnyBody Modeling System (03:47) Introduction to Hugo Giambini's presentation (11:33) Research aim: Estimate spine joint contact forces from daily living activities (17:20) Study design and method (21:33) Validation efforts: Wilke et al. 2001 (24:16) Results: L4-L5 Contact forces (27:02) Residual forces (33:14) Conclusion (37:53) AnyBody online resources and upcoming events