Organic Chemistry Masterclass: Insanely complex neuroprotective Illisimonin A (+reaction mechanisms) скачать в хорошем качестве

Organic Chemistry Masterclass: Insanely complex neuroprotective Illisimonin A (+reaction mechanisms)

⚠️ This video contains advanced organic chemistry! Illisimonin A is the perfect quest for synthesis practicioners - it is bioactive (neurotrophic), structurally complex and highly oxygenated. This video will explain the isolation of this illicium-derived natural product and properties. Two modern syntheses (2019 and 2023) will be discussed, highlighting unique approaches and common methodologies to access this interesting target. https://total-synthesis.com/organic-c... 🧑‍🎓➡️ Free organic chemistry practice problems   / totalsynthesis   🚀 Thanks to all channel supporters!!!   / totalsynthesis_official   👉 Follow me on Instagram to follow updates on other random chemistry research and interesting news! https://www.total-synthesis.com Please drop a like and comment to support the video's visibility, activate notifications and subscribe to the channel so you do not miss future videos! 00:00 Why we should care about illicium natural products 00:47 How it was discovered, isolated and characterized 01:40 The property that makes it exciting¨ 02:49 Retrosynthetic analysis and key late-stage disconnections 04:53 Rychnovsky: First total synthesis (racemic) and structural revision 08:29 Kalesse: Asymmetric total synthesis 13:43 Closing remarks Key references: Asymmetric Total Synthesis of Illisimonin A (J. Am. Chem. Soc. 2023, 145, 7021) Total Synthesis and Structure Revision of (−)-Illisimonin A, a Neuroprotective Sesquiterpenoid from the Fruits of Illicium simonsii (J. Am. Chem. Soc. 2019, 141, 13295) Illisimonin A, a Caged Sesquiterpenoid with a Tricyclo[5.2.1.01,6]decane Skeleton from the Fruits of Illicium simonsii (Org. Lett. 2017, 19, 6160) Other related publication: Synthesis of Illisimonin a Skeleton by Intramolecular Diels–Alder Reaction of Ortho-Benzoquinones and Biomimetic Skeletal Rearrangement of Allo-Cedranes (Organics 2021, 2, 306) Some recommended books on organic synthesis: Clayden, Greeves, Warren; Organic Chemistry (basic organic chemistry knowledge) Wyatt, Warren; Organic Synthesis: The Disconnection Approach (excellent introduction to retrosynthesis) Kurti, Czako; Strategic Applications of Named Reactions in Organic Synthesis (extensive toolkit of functional group reactions and applications thereof with common conditions) Nicolaou; Classics in Total Synthesis 1-3 (the ultimate total synthesis trilogy) Nicolaou; Molecules That Changed the World (the world's most important molecules and their impact on everyday life) Carreira, Kvaerno; Classics in Stereoselective Synthesis (compilation of the groundbreaking methods of stereoselective synthesis and application to synthesis of stereochemically complex structures)