Ep. 102 - Psychiatry R&D: Steve Paul on Serendipity, Engineering and What Drives Real Breakthroughs скачать в хорошем качестве

Ep. 102 - Psychiatry R&D: Steve Paul on Serendipity, Engineering and What Drives Real Breakthroughs

With disease biology still murky and trials notoriously noisy, psychiatry R&D is advancing fastest where teams can solve engineering problems. Delivery, selectivity and tolerability fixes are turning long-standing hypotheses into usable medicines, says veteran CNS drug developer Steven Paul. Few drug developers have had a closer view of the field’s false starts — and occasional breakthroughs — than Paul, who has moved from NIH to pharma R&D leadership and now to company building at Karuna, acquired by BMS for $14 billion, and Seaport. In conversation with The BioCentury Show's Selina Koch, Paul explains why serendipity still plays a disproportionate role in psychiatric drug development and how critical it is for teams to engineer and execute their way from an unexpected signal to a usable medicine. He also discusses psychedelics, brain shuttles, Karuna’s muscarinic approach (https://www.biocentury.com/article/65...) in schizophrenia, and the delivery and trial-design choices Seaport is using to revisit neuroactive steroid (https://www.biocentury.com/article/65...) biology in depression. View full story: https://www.biocentury.com/article/65... #PsychiatryTherapeutics #CNSDrugDevelopment #BiotechEngineering #Psychedelics #NeuroScience 00:00 - Introduction 01:35 - Psychiatric Drug Discovery 06:59 - The Karuna Story 22:08 - What’s New in Depression 32:05 - Gene Therapies, Brain Shuttles 33:52 - Psychedelics