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Barbituates Mnemonic for USMLE

Study this Barbituates mnemonic and other mnemonics with Pixorize. Barbiturates are a class of drugs that include phenobarbital, secobarbital, pentobarbital, and thiopental. These drugs work by increasing GABA signaling in the brain. After binding to the GABA-A receptor, they prolong the duration that chloride channels stay open after binding by GABA. In general, an increase in GABA signaling causes depressant effects on the brain as GABA is an inhibitory neurotransmitter. As such, Barbiturates are clinically used to treat seizures, especially in neonates. Barbiturates may also be used to induce sedation, which is helpful in treating insomnia, anxiety, and for inducing anesthesia. Notably, barbiturates induce CYP or cytochrome P450 enzymes, so be on the lookout for drug interactions. Barbiturates are also associated with significant CNS and cardiorespiratory depression that can be fatal, and must be treated with supportive ventilatory support and oxygen. Additionally, there is a risk of developing tolerance or dependence with continued use of barbiturates. Finally, barbiturates can cause acute intermittent porphyria and should be avoided in patients with this condition. Subscribe for more: https://bit.ly/2yybxhm Study interactive image: https://pixorize.com/view/6437 #USMLE #Step1 #Pharm #barbituates