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This session is presented by Brandon Hayes-Lattin, MD. Session Abstract The emergence of the field of adolescent and young adult (AYA) oncology was led by analyses of the epidemiology of cancer occurring across a span of ages from childhood to older adulthood. Trends demonstrated multiple unique aspects that defined the population to be studied as those diagnosed at ages 15-39, including differences in the incidence of various cancers among AYAs and varied rates of survival outcomes. Further study has demonstrated that differences in the underlying biology of cancers that occur in the AYA age range can explain many of these trends. In this session, we will review the epidemiology of AYA cancer and the unique biology associated with cancers diagnosed in the AYA age range. Dr. Brandon Hayes-Lattin serves as Professor of Medicine and Deputy Division Head in the Division of Hematology and Medical Oncology at Oregon Health and Science University, and Director of the OHSU Knight Cancer Institute’s Adolescent and Young Adult (AYA) Oncology Program. His clinical background is in the management of hematologic malignancies and the use of cellular therapies and hematopoietic stem cell transplantation. As a young adult cancer survivor himself, and a physician caring for many young adults with hematologic malignancies, Dr. Hayes-Lattin has taken a leadership role in the development of the discipline of AYA Oncology. He has served as the Senior Medical Advisor to the LIVESTRONG Foundation, the Chief Medical Officer for Critical Mass: The Young Adult Cancer Alliance, the inaugural Chair of the AYA Committee for SWOG, participated on the expert advisory panel to the Children’s Oncology Group AYA Committee, as a member of the CDC’s Federal Advisory Committee on Breast Cancer in Young Women, and on the Committee on Childhood Cancers and Disability for the National Academies of Sciences, Engineering, and Medicine.