Folate Receptors in Pediatric Tumors Enable Intraoperative Imaging With Pafolacianine | Oncotarget скачать в хорошем качестве

Folate Receptors in Pediatric Tumors Enable Intraoperative Imaging With Pafolacianine | Oncotarget

Oncotarget #published this #research paper on October 16, 2025, in Volume 16, entitled “Widespread folate receptor expression in pediatric and adolescent solid tumors - opportunity for intraoperative visualization with the novel fluorescent agent pafolacianine" by #researchers from the Department of Surgery, Ann & Robert H. Lurie Children’s Hospital, Chicago, IL; Department of Pathology and Laboratory Medicine, Ann & Robert H. Lurie Children’s Hospital, Chicago, IL; Stanley Manne Children’s Research Institute, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL; Division of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Ann & Robert H. Lurie Children’s Hospital, Chicago, IL; Division of Pediatric Surgery, Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL. ‪@LurieChildrens‬ ‪@NUFeinbergMed‬ #cancer #oncology #tumors #pafolacianine #pediatriconcology #pediatrics #openaccess #openscience #peerreview #journal #publication #publishing #meded DOI - https://doi.org/10.18632/oncotarget.28772 Correspondence to - Timothy B. Lautz - [email protected] Abstract Contemporary fluorescence-guided surgery has evolved principally based on the uses and limitations of the contrast agent indocyanine green (ICG). A second generation of novel fluorescent agents are under development to target specific molecular markers on tumor cells and/or the tumor micro-environment. Pafolacianine, a molecular agent targeting the folate receptor (FR), is the first of these approved for use in adults, but its potential utility in pediatric cancers is unknown. In this study, we performed immunohistochemistry staining on slides obtained from a range of pediatric patients with solid tumors. Slides were stained with antibodies to FRα and FRβ, and fluorescence was quantified. Separately, publicly available RNA sequencing data were queried for both FRα and FRβ expression in various pediatric tumors. Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/e... Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, folate receptor, fluorescent-guided surgery, pediatric tumors, pafolacianine, RNA sequencing About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science). To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube -    / @oncotargetjournal   LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJz... [email protected]