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With ongoing studies on both MIS sICH evacuation and percutaneous PE thrombectomy, Mount Sinai reports a notable case of combined percutaneous PE thrombectomy and MIS sICH evacuation with remarkable results. This case of sICH was complicated by a concomitant massive pulmonary embolism causing hemodynamic compromise. Endovascular thrombectomy was combined with surgiscopic sICH evacuation to provide a novel treatment strategy for a patient with high expected morbidity and mortality based on her disease process. Both interventions were performed in the same operating theater and led to a remarkable improvement for this patient, a 57-year-old woman with an initial National Institutes of Health Stroke Scale (NIHSS) score of 23. On 3-month follow-up, her NIHSS score was 0. The case is narrated by Christopher P. Kellner, MD, Assistant Professor of Neurosurgery at the Icahn School of Medicine at Mount Sinai, Director of the Intracerebral Hemorrhage Program, and Principal Investigator of the Cerebrovascular Translational Laboratory. Dr. Kellner also serves as Associate Director of the Neurosurgery Residency Program.