MPCCC Tech Talk: Claire Sun and Paul Daniel скачать в хорошем качестве

MPCCC Tech Talk: Claire Sun and Paul Daniel

The Childhood Cancer Model Atlas (CCMA). Paediatric solid tumours are the leading cause of cancer related death amongst children. Identification of paediatric-specific targeted therapies necessitates the use of paediatric cancer models that faithfully recapitulate the patient’s disease. In adult cancers, comprehensive cell line repositories and data atlases have enabled both hypothesis-driven research and scalable screens for new therapies. The generation and characterisation of paediatric cancer cell lines has significantly lagged behind that of their adult counterparts, underscoring the urgent need to develop a paediatric-focussed cell line resource. This talk will introduce the Childhood Cancer Model Atlas (CCMA), a comprehensive collection of 243 cell lines, featuring 207 pediatric cancer cell lines spanning 14 different types of extracranial and brain childhood tumors. We will also illustrate how we are utilizing this invaluable resource to uncover essential insights into the realm of childhood cancers.