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The John Karling Annual Lecture is MSA's most prestigious invited talk and is presented this year by Barbara Howlett, a professor in the Department of Botany at the University of Melbourne in Australia. Howlett is a frequently called upon expert with respect to agriculture and enhancing crop production in Australia. She leads a national team that developed disease management strategies that are widely adopted by Australian farmers. Howlett jointly led an international team that acquired and annotated the genome sequence for the fungus Leptosphaeria maculans. Bioinformatic analysis of this sequence led to the development of high-throughput molecular tests that monitor virulent fungal populations and predict disease outbreaks on canola crops across Australia. She serves on the editorial board of Eukaryotic Cell and has been an associate editor of PLOS Pathogens and PLOS ONE and a senior editor of Molecular Plant Pathology. Howlett is an elected fellow of the American Academy of Microbiology.