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For more detail, please visit http://www.annalscts.com/article/view... Following the success and rapid adoption of transcatheter aortic valve replacement (TAVR), a procedural, catheter-based approach to mitral valve pathology and options for replacement of the mitral valve quickly became an obvious target for investigators and industry. In this keynote lecture, the experienced team of Moritz Wyler von Ballmoos, Ankur Kalra and Michael J. Reardon discuss how adoption of TMVR will require overcoming the anatomic challenges as well as generating data that supports improved survival and/or quality of life. Cite this article as: Wyler von Ballmoos MC, Kalra A, Reardon MJ. Complexities of transcatheter mitral valve replacement (TMVR) and why it is not transcatheter aortic valve replacement (TAVR). Ann Cardiothorac Surg 2018;7(6):724-730. doi: 10.21037/acs.2018.10.06 The Annals of Cardiothoracic Surgery (ACS) is a bi-monthly peer-reviewed scientific journal, focusing on the latest clinical evidence and surgical techniques. For more information regarding upcoming issues and manuscript submissions please visit www.annalscts.com.