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Finding the right treatment for Irritable Bowel Syndrome with Constipation (IBS-C) can feel overwhelming, but understanding how different therapies work can make all the difference. In this episode, we dive deep into two key treatment categories: secretagogues and retainagogues—what they are, how they work, and why they matter for IBS-C patients. Joining us is Dr. Darren Brenner, a leading expert in neurogastroenterology and motility disorders from Northwestern University. He breaks down the science behind these treatments, shares expert insights, and helps us understand when and why providers may recommend them. Don’t miss this expert-led conversation that makes IBS-C treatments clearer than ever! This episode is made possible with support from Ardelyx. About the Gastro Girl Podcast In each episode, host Jacqueline Gaulin, podcast creator, longtime patient advocate and the Founder of Gastro Girl, will tackle topics that go beyond the basic mainstream coverage of GI health to educate, inform and empower patients and their caregivers. If you crave the inside scoop on the latest news, research and resources related to gastroenterology, and want it all delivered in an engaging, friendly, nonjudgmental and educational way that features leading GI experts, inspiring patients and positive vibes, this podcast is also for you. Gastro Girl, an official patient-education partner of The American College of Gastroenterology, is committed to providing actionable and evidence-based health information to help empower patients to better health. Have a question or a digestive health-related topic you'd like us to address on an upcoming episode? Are you a patient who wants to share their story? Please email us [email protected] Looking for expert-backed digestive health support? The Ask Gastro Girl App is your trusted AI-powered companion, offering quick answers, symptom tracking, personalized nutrition plans, and more. Download now to take charge of your gut health: https://gastrogirl.com/ask-gg-app/ For more info: https://www.gastrogirl.com https://www.gi.org/patients Follow Gastro Girl Facebook / gastrogirlinc Instagram / gastrogirl_inc Twitter / gastrogirl Follow ACG Facebook / amcollegegastro Instagram / amcollegega. . Twitter / amcollegegastro Disclaimer: The sole purpose of the Gastro Girl podcast is to provide educational and informational content. Gastro Girl, Inc., American College of Gastroenterology, The Gastro Girl Podcast, host, Jacqueline Gaulin, and any and all guests appearing on any Gastro Girl podcast episode [Collectively the Service Provider] do not provide any medical advice and the Information will not be so construed or used as medical advice. Using, accessing and/or listening to the Gastro Girl Podcast and/or providing personal or medical information to the Service Provider does not create a clinician-patient relationship between the Service Provider and you or your patients. Nothing contained in this or any Gastro Girl Podcast episode is intended to create a clinician-patient relationship, and you will not rely on anything contained in any podcast episode in diagnosing or treating yourself or anyone else. THE INFORMATION CONTAINED IN THESE PODCAST EPISODES IS PROVIDED FOR EDUCATIONAL PURPOSES ONLY AND IS NO WAY INTENDED TO DIAGNOSE, CURE OR TREAT ANY MEDICAL OR OTHER CONDITION. PLEASE CONTACT YOUR HEALTHCARE PROVIDER WITH ANY QUESTIONS RELATED TO YOUR HEALTH AND WELLBEING. If YOU ARE EXPERIENCING A HEALTH Emergency Please CALL 911