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Watch the Full Video at https://www.jove.com/v/51093/primary-.... Primary Culture of Human Vestibular Schwannomas - a 2 minute Preview of the Experimental Protocol Nathan M. Schularick, J. Jason Clark, Marlan R. Hansen University of Iowa Hospitals and Clinics, Department of Otolaryngology-Head and Neck; Vestibular Schwannomas (VSs) are non-malignant tumors of Schwann cell (SC) origin, associated with mutations in the NF2 tumor suppressor gene. We report a reproducible, efficient protocol for primary human VS cell culture that allows for molecular and cellular experimental manipulation and analysis and recapitulates the heterogeneous nature of human disease. Visit https://www.jove.com?utm_source=youtu... to explore our entire library of 14,000+ videos of laboratory methods and science concepts. JoVE is the world-leading producer and provider of science videos with the mission to improve scientific research and education. Millions of scientists, educators, and students at 1500+ institutions worldwide, including schools like Harvard, MIT and Stanford benefit from using JoVE's extensive library of 14,000+ videos in their research,education and teaching. Subscribe to our channel: / jovejournalofvisualizedexperiments