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Part 1 of a 4 part series featuring excerpts from Sir Paul Nurse’s lecture “The Fundamental Significance of Discovery Science in the Creative Process” for the 2015 Henry G. Friesen International Prize in Health Research. Sir Paul Nurse is the Chief Executive and Director of the Francis Crick Institute, a consortium of six of the UK’s most successful scientific and academic organisations, and was also the past President of the Royal Society of London. He was awarded the 2015 Henry G. Friesen International Prize in Health Research. Sir Nurse is a distinguished geneticist and cell biologist, science advocate, and policy maker. He is passionate about encouraging the next generation of scientists to explore their curiosity. Sir Paul Nurse received the Nobel Prize in Physiology or Medicine in 2001. In this clip, Sir Paul Nurse discusses the personal qualities that make people good scientists. Sir Nurse states that some of the important traits for science are courtesy, humility, and courage, along with creativity, skepticism, honesty, and transparency. Courtesy is essential for scientific dispute and debate. Referencing Sir Francis Bacon, humility and self-doubt are significant because starting with doubt is more likely to end in certainty, then starting with certainty which ends in doubt. Courage is important because new scientific discoveries frequently challenge accepted thinking; for example, when Darwin proposed the theory of evolution. Overall, these qualities put together will give insights into the natural world and the revolutionary process of science. Filmed at the University of Ottawa on December 7, 2015. For more information about FCIHR and our various programs/projects, please visit our website: http://www.fcihr.ca/