Antiplatelet Medications | Mechanism of Action, Indications, Adverse Reactions, Contraindications скачать в хорошем качестве

Antiplatelet Medications | Mechanism of Action, Indications, Adverse Reactions, Contraindications

Official Ninja Nerd Website: https://ninjanerd.org Ninja Nerds! In this cardiovascular pharmacology lecture, Professor Zach Murphy provides a clear and high-yield breakdown of Antiplatelet Medications, focusing on their mechanisms of action, clinical uses, and pharmacologic distinctions. We begin by reviewing the physiology of platelet activation and aggregation, including the roles of TXA₂, ADP, and GP IIb/IIIa receptors in forming the platelet plug. Building on this, we explore how different drug classes interrupt this cascade to reduce thrombus formation. The lecture covers the major classes of antiplatelet agents: • COX-1 inhibitors: Aspirin—irreversible inhibition of thromboxane A₂ synthesis • P2Y₁₂ receptor inhibitors: Clopidogrel, Prasugrel, Ticagrelor—blocking ADP-mediated platelet activation • GP IIb/IIIa inhibitors: Abciximab, Eptifibatide, Tirofiban—preventing final common pathway of platelet aggregation • Phosphodiesterase inhibitors: Dipyridamole, Cilostazol—increasing cAMP to inhibit platelet function We also discuss clinical indications such as acute coronary syndromes, stroke prevention, post-PCI management, and peripheral artery disease, while covering important side effects, drug interactions, and contraindications. Enjoy the lecture and support us below! 🌐 Official Links Website: https://www.ninjanerd.org Podcast: https://podcast.ninjanerd.org Store: https://merch.ninjanerd.org 📱 Social Media   / ninjanerdlectures     / ninjanerdlectures     / ninjanerdlectures   https://x.com/ninjanerdsci/   / ninja-nerd   💬 Join Our Community Discord:   / discord   #ninjanerd #antiplateletdrugs #pharmacology