Health Data Research (HDR) UK Multi-'omics Cohorts Consortium - Insight Sharing Day 14.04.21 скачать в хорошем качестве

Health Data Research (HDR) UK Multi-'omics Cohorts Consortium - Insight Sharing Day 14.04.21

The Multi-'omics Cohorts Consortium, funded by Health Data Research (HDR) UK and led by Professor Adam Butterworth (University of Cambridge), ran from March 2020 to Dec 2022. The aim was to bring together large datasets from across the UK to predict and understand the causes of disease. Genetics has transformed our understanding of how variation in DNA can influence risk of developing conditions, such as cancer and heart disease. Studies that can combine this genetic information with other blood-based factors – including proteins, metabolites and lipids (= 'omics) – and health records, have the potential to provide more direct insight into disease aetiology and prediction. A key challenge so far, however, has been accessing this information at sufficient scale. The Multi-'omics Cohorts Consortium aimed to address this challenge by bringing together information on participants from multiple studies to enhance scientific power, breadth, and robustness. The Consortium brought together existing and unique data assets, maximising their value within an open and collaborative national team. In this video, you can hear talks about: Introduction to this project (Adam Butterworth, Cambridge) Genetic imputation of biomolecular traits to enable multi-domain analyses (Mike Inouye, Cambridge) Applications of 'omics to the China Kadoorie Biobank (Michael Holmes, Oxford) Cross-platform integration of -'omic data at scale (Maik Pietzner, Cambridge) Biological insights through integration of genomics and metabolomics (Joanna Tzoulaki, Imperial College) [BREAK] Public involvement in this project: achievements, challenges and future aims (Amanda Stranks, Sarah Fahle, Chris Cuninghame) Indirect genetic effects in the causation of disease (Albert Tenesa, Edinburgh) Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19 (Liam Gaziano, Cambridge) Proteomic Mendelian randomisation suggests a novel mechanism underlying severe COVID-19 (Lucija Klaric, Edinburgh) Follow us on Twitter: @CAMBRIDGE_CEU and @aidanbutty HDR UK Multi-'omics Cohorts Consortium: https://www.hdruk.ac.uk/projects/a-na... HDR UK: https://www.hdruk.ac.uk NIHR Cambridge Biomedical Research Centre: https://cambridgebrc.nihr.ac.uk/resea... Videos suitable for a public audience:    • Videos Designed for a Public Audience - al...