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Dr Cacciottolo's research focuses on cellular mechanisms which are disrupted in people with severe obesity due to rare genetic mutations. In this short expert talk, 'Rare variants in Steroid Receptor Coactivator (SRC-1) associated with severe obesity', Dr Cacciottolo explains her work on the homeostatic mechanisms regulating body weight. In particular, she is using mouse models to research rare genetic changes affecting how the hormone leptin functions within cells, and so consequently how the body to suppress appetite after eating. Dr Tessa Cacciottolo is a Wellcome Trust Clinical Research Fellow at the Wellcome-MRC Institute of Metabolic Science, University of Cambridge. Our Clinical Academics in Training Annual Conference, or CATAC, offers early career researchers the chance to present work and receive feedback from senior panelists in a truly interdisciplinary setting. The conference gives clinical academics the chance to meet people from all areas of biomedical science, and share ideas from many different perspectives. Read more about the 2018 meeting https://acmedsci.ac.uk/grants-and-sch... Read more about past Spring Meetings https://acmedsci.ac.uk/grants-and-sch... We are the independent body in the UK representing the diversity of medical science. Our mission is to advance biomedical and health research and its translation into benefits for society. CATAC 2018 was held in the Academy of Medical Sciences 20th year. Read about the Academy's achievements in its first 20 years at https://acmedsci.ac.uk/ams20 Follow the Academy of Medical Sciences' Careers Team on Twitter: / ams_careers Find the Academy of Medical Sciences online: Website: http://acmedsci.ac.uk/ Twitter: / acmedsci Facebook: / acmedsci Instagram: / acmedsci