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In this exclusive video compilation, hear directly from leading experts as they share their top highlights in myeloproliferative neoplasms (MPNs) from the 66th ASH Annual Meeting and Exposition, held in San Diego, CA. This roundup features: • Claire Harrison, who highlights the importance of increasing our understanding of MPN genomics, the excitement around novel JAK inhibitors, and promising ongoing trials, including the MANIFEST trial (NCT02158858); • John Mascarenhas, who highlights the impact of TP53 mutations in patients with MPNs, novel JAK inhibitor and non-JAK inhibitor therapies, and immunotherapeutic approaches; • Prithviraj Bose, who discusses research on CALR variant allele frequency (VAF) dynamics, findings from the FREEDOM2 study (NCT03952039), and rethinking risk stratification in polycythemia vera (PV); • Lucia Masarova, who discusses the excitement regarding the combination of ruxolitinib and selinexor, the BOREAS trial (NCT03662126), and other novel agents, including nuvisertib. These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.