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What happens after GLP-1s? In this episode of The Downsized, Christopher Durham sits down with Harith Rajagopalan, MD, PhD, cardiologist and CEO of Fractyl Health, to break down new clinical trial results that could reshape how we think about obesity treatment. The data tackles one of the biggest unanswered questions in obesity care today: 👉 What do you do when you stop a GLP-1 and don’t want the weight to come back? Harith explains Fractyl’s investigational, non-surgical procedure designed to target the root cause of obesity in the gut, not just manage symptoms. In real-world and blinded clinical studies, patients who stopped GLP-1 therapy regained far less weight than expected, with some continuing to lose weight—without ongoing medication. We cover: New trial results focused on preventing weight regain after GLP-1s Why obesity and type 2 diabetes may start in the duodenum How this outpatient endoscopic procedure works What the data shows on weight durability and blood sugar How this approach compares to lifelong medications and bariatric surgery What FDA breakthrough device designation could mean for timing and access Learn more about Fractyl Health and their research here: 👉 https://www.fractylhealth.com +++++++++++++++++++++++++++++++++++++++ Start your weight loss journey today! We use Mochi Health: https://app.joinmochi.com/eligibility... Use Laraine’s code for $40 off: QIYGO8. Me Again Iphone GLP-1 App: https://apps.apple.com/us/app/meagain... Get your Hume BodyPod today and use our exclusive Downsized code for an extra 20% off on top of the sitewide sale—up to 50% total savings! 👉 Use our Code: THEDOWNSIZED Link to purchase: https://humehealth.com//discount/THED... To receive 20% off your Purchase of Biocare Protein Bars or Shakes, visit https://biocarenutrition.com/DOWNSIZED and enter the discount code DOWNSIZED AMAZON GLP-1 Companion Product Store: https://www.amazon.com/shop/downsized As an Amazon Associate, I earn from qualifying purchases. DOWNSIZED LINKS Https://Thedownsized.Org/ Book The Downsized At Sea Cruise 2026: Https://Thedownsized.Org/Downsized-At... FOR SPONSORSHIPS, BRAND DEALS & COLLABS: https://thedownsized.org/contact/ +++++++++++++++++++++++++++++++++++++++ 00:00 Introduction and Obligatory Disclaimers 00:50 Meet Harith Rajagopalan: CEO of Fractyl Health 01:17 Understanding Obesity and Diabetes 02:38 The Car Analogy: Treating Symptoms vs. Root Causes 07:04 The Role of the Gut in Obesity and Diabetes 13:52 Introducing Reda: A New Procedural Therapy 19:50 Clinical Trials and Promising Results 24:23 Future Prospects and Final Thoughts