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INTERSTITIUM

The interstitium is a contiguous fluid-filled space existing between the skin and the body organs, including muscles and the circulatory system The interstitial fluid is a reservoir and transportation system for nutrients and solutes distributing among organs, cells, and capillaries, for signaling molecules communicating between cells, and for antigens and cytokines participating in immune regulation.[2] The composition and chemical properties of the interstitial fluid vary among organs and undergo changes in chemical composition during normal function, as well as during body growth, conditions of inflammation, and development of diseases,[2] as in heart failure[5] and chronic kidney disease Preliminary research of the interstitium in people with lung diseases, heart disease, cancer, kidney disease, immune disorders, and periodontal disease indicates that the interstitial fluid and lymph system are sites where disease mechanisms may arise or develop