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Julien Taieb, MD, PhD, Paris Descartes University, Paris, France, discusses circulating tumor DNA (ctDNA) as an indicator for disease recurrence following resection of non-metastatic colorectal cancer. Currently, all patients are treated further following this resection to prevent recurrence, inevitably exposing healthy patients to drug toxicities. Identifying patients who are unlikely to experience recurrence (those with low/no ctDNA) could combat this, though it is still necessary to generate more knowledge surrounding which tests to use and when. This interview took place at the European Society for Medical Oncology (ESMO) 2023 Congress in Madrid, Spain. These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.