Breast-conserving therapy yields better 10-year outcomes than mastectomy for early-stage patients скачать в хорошем качестве

Breast-conserving therapy yields better 10-year outcomes than mastectomy for early-stage patients

Dr Siesling talks to ecancertv at SABCS 2015, about the results of a large population-based study that compared the 10-year overall survival (OS) and disease-free survival (DFS) after breast-conserving therapy plus radiotherapy with mastectomy without radiation therapy in Dutch women with early stage breast cancer. The study considered data on 37,207 women diagnosed with primary invasive early (T1-2N0-1M0) breast cancer over a 4-year period staring in 2000. Of these 58% had received breast-conserving surgery with radiotherapy and 42% had undergone mastectomy. The respective 10-year OS were 76.8% and 59.7%. Although DFS was similar, patients who had breast-conserving treatment were less likely to experience distant metastases or regional recurrence. Dr Siesling observes that the additional radiotherapy may be responsible for the better OS seen in the breast-conserving arm, although residual factors could explain part of the difference in recurrences.