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Neuroendocrine tumors (NETs) are a special type of neoplasm that develops from hormone-producing cells. The ileum, the final part of the small intestine, is one of the most common sites of origin. 🔹 How common are they? NETs of the small intestine account for about 30–40% of all gastrointestinal NETs, with a median age at diagnosis of around 60 years. In many cases, the tumor is detected incidentally during CT or colonoscopy performed for another reason. 🔹 Clinical features These tumors tend to grow slowly, but they can metastasize early to regional lymph nodes or the liver. Some are functionally active, producing hormones that lead to the carcinoid syndrome — flushing, diarrhea, and palpitations. 🔹 Prognosis and treatment Despite their potential to metastasize, ileal NETs usually have a favorable prognosis. The 5-year survival rate reaches 90–95% for localized disease and about 60% for metastatic cases. 🔹 Surgery remains the cornerstone of treatment. The standard approach is ileal resection with lymphadenectomy. Even when metastases are present, removal of the primary tumor can improve survival and reduce hormonal symptoms. In selected cases, therapy with somatostatin analogs, targeted drugs, or radionuclide therapy may be added. 💬 Neuroendocrine tumors are not a death sentence — they are chronic but manageable conditions. With early diagnosis and proper treatment, patients can live for decades with good quality of life.