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Pneumocytes (or alveolar cells) are the cells that line the alveoli and comprise of the majority of the inner surface of the lungs There are two types of alveolar cells – type I pneumocytes and type II pneumocytes Type I pneumocytes Type I pneumocytes are involved in the process of gas exchange between the alveoli and the capillaries They are squamous (flattened) in shape and extremely thin (~ 0.15µm) – minimising diffusion distance for respiratory gases Type I pneumocytes are connected by occluding junctions, which prevents the leakage of tissue fluid into the alveolar air space Type I pneumocytes are amitotic and unable to replicate, however type II cells can differentiate into type I cells if required Type II pneumocytes Type II pneumocytes are responsible for the secretion of pulmonary surfactant, which reduces surface tension in the alveoli They are cuboidal in shape and possess many granules (for storing surfactant components) Type II pneumocytes only comprise a fraction of the alveolar surface (~5%) but are relatively numerous (~60% of total cells) #pneumocyte