Lessons in LAI: Discovery of a Long-Acting Injectable TAK1 Inhibitor скачать в хорошем качестве

Lessons in LAI: Discovery of a Long-Acting Injectable TAK1 Inhibitor

LAI (long-acting injectable) medical products offer a combination of a drug substance and a formulation that provides consistent exposure of the affected tissue to the active molecule for an extended therapeutic treatment period without eliciting unwanted side effects. While marketed LAI drugs typically owe their success to a formulation principle that is adequately tailored to the drug substance, there is no comprehensive overview of how drug molecules can be designed in a smart way to facilitate and accelerate technical formulation development at a later stage. In this Flash Talk, Thomas and Jean-Baptiste discuss the key properties of low-molecular-weight drugs that are suitable for different LAI formulations and describe the discovery of TAK-756, a potent inhibitor of TAK1 kinase, to treat osteoarthritis through intra-articular injection of a long-acting microcrystal suspension. 00:00 Welcome and Introduction 14:29 New Drug Hunter Feature - Calculators 17:00 Presentation 53:09 Q&A If your company doesn’t have a subscription yet, reach out here to inquire about access: https://drughunter.com/plans Recorded on September 4th 2025, as a Drug Hunter Flash Talk. Sign up to be notified of future sessions here: https://drughunter.com/flash-talk-ser... Sign up for our free newsletter here: https://drughunter.com/newsletter-sig...