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#23330

Natural history of lower urinary tract symptoms in treatment-seeking women with pelvic organ prolapse Kowalski J1, Wiseman J2, Cameron A3, DeLancey J3, Hendrickson-Cahill W4, Jelovsek E4, Kirby A5, Kreder K1, Lai H6, Mueller M7, Siddiqui N4, Bradley C1 1. University of Iowa, 2. Arbor Research Collaborative for Health, 3. University of Michigan, 4. Duke University, 5. University of Washington, 6. Washington University in St. Louis, 7. Northwestern Medicine KEYWORDS: Pelvic Organ Prolapse, Prolapse Symptoms, Prospective Study The natural history of overactive bladder (OAB) and other lower urinary tract symptoms (LUTS) in women with pelvic organ prolapse (POP), both treated and untreated, is not well characterized. Women seeking care for bothersome LUTS at six tertiary centers were enrolled in an observational study and assessed a wide range of LUTS using the LUTS Tool at baseline, 3 months and 12 months. Our aims were to (1) determine baseline association between LUTS Tool scores and POP and (2) compare change in LUTS Tool scores from baseline to 12-months in women with and without POP. We hypothesized that the LUTS Tool scores would be associated with the presence of POP and that LUTS Tool responses are stable over time in patients with and without POP at baseline.