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Learn the latest on Therapeutic Hypothermia and HIE management in LMICs. Dr. Khalid Haque discusses the HELIX trial and the risks of Neonatal Cooling in resource-limited settings.. In this APPNA Pediatrics lecture, we provide a deep dive into Neonatal Encephalopathy and the controversy surrounding Therapeutic Hypothermia in low and middle-income countries. While Cooling Therapy is the gold standard for HIE treatment in the West, recent data from the HELIX trial suggests it may increase newborn mortality in LMICs like Pakistan and India. We explore the impact of Perinatal Asphyxia, the role of Neonatal Sepsis, and how Maternal Malnutrition affects brain recovery. Dr. Khalid Haque, a leading expert in Neonatology, explains why Intensive Care standards must be adapted for resource-limited environments. This guide covers Newborn Resuscitation, Neuroprotection, and the transition to Normothermia as a safer alternative to aggressive cooling. Essential for anyone in Pediatric Intensive Care or Global Health Pediatrics, this session redefines the standard of care for Neonatal Encephalopathy in 2026. Timestamped Chapters: 00:00 - Introduction: The HIE Crisis in LMICs 05:30 - Why "Standard of Care" Fails in Resource-Limited Settings 12:45 - The HELIX Trial: Analyzing the Shocking Results 21:10 - Sepsis vs. Asphyxia: The Overlooked Connection 30:45 - High-Tech vs. Low-Tech Cooling Devices 39:20 - Is It Time to Abandon Hypothermia in LMICs? 48:15 - Future Strategies for Neonatal Neuroprotection Watch Our Other Videos & Resources 1 / @appnapediatrics 2 / @appnapediatrics 3 • Lectures 4 / @appnapediatrics 5 https://appnapeds.org 6 https://appnapeds.org/links/ 7 https://appnapediatrics.org/ 8 / posts