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Your Medication Pioglitazone Pioglitazone is also known as the brand name: Actos Pioglitazone comes as a tablet dosage form. Pioglitazone is most commonly used for type 2 diabetes. Pioglitazone is usually taken once daily by mouth with or without food. It is important to follow a healthy diet and to exercise. Standard dosing of pioglitazone ranges from 15 mg to 45 mg daily Some common side effects with pioglitazone include swelling in hands or feet, lightheadedness or shaking, runny nose, and sore throat. Some less common side effects with pioglitazone include headache, heart failure, and muscle and bone weakness. Do not take pioglitazone if: • You have heart failure • You are allergic to pioglitazone While taking pioglitazone, remember it is important to tell your doctor or pharmacist if you: • Have signs of an allergic reaction, such as rash, itching, swelling, or tightness of the chest • Experience changes in your vision or blurred vision. • Have blood in your urine, pain when you urinate, increase in the amount of urine you make daily, or pain in the lower back • Start taking new medications, vitamins, or supplements. Pioglitazone may weaken your bones; so discuss with doctor or pharmacist a way to keep them strong.