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PCRI’s Executive Director, Mark Scholz, MD, talks about temporary radioactive seed implants as a treatment for men with the Teal stage of prostate cancer. He covers the pros and cons of the treatment, discusses practical considerations, and compares it to other standard treatments for Teal. Don’t know your stage? Take the quiz: Visit http://www.prostatecancerstaging.org To learn more about prostate cancer visit http://www.pcri.org To download the free Staging Guide visit http://www.pcri.org/prostate-cancer-s... 0:21 There are two types of radioactive seed implants, permanent, and temporary. Permanent seeds, which are more popular, are placed in an outpatient procedure whereas temporary seeds are administered while the patient is in the hospital. A top priority when considering brachytherapy of any kind is finding an experienced doctor who will do the procedure. Cure rates and side effects between permanent and temporary seeds are comparable. 1:22 Adding external beam radiation to a seed implant. Men with Basic Teal, as laid out in the PCRI staging guide typically doesn’t need external beam radiation, however, men with High Teal should consider adding a course of external beam radiation because studies show better disease control. 2:06 What are temporary seeds? Catheters are placed into the prostate through the perineum, the skin between the scrotum and the anus. A radioactive iridium seed is placed in the catheters and slowly drawn out. This cycle is repeated every 6-8 hours or so. The catheters have to remain in place throughout the hospital visit. Temporary seeds are a more involved procedure than permanent seeds. 3:27 Advantages of temporary seeds. There is some suggestion that HDR brachytherapy can have better anti-cancer effects due to the higher rate that the radiation is delivered. With permanent seeds, the seeds can only be placed in the gland, whereas with temporary seeds the catheters can be placed around the gland which can help the doctor steer the radiation outside the prostate. This is especially important if the seminal vesicles need to be treated. 4:19 Side effects of brachytherapy. Side effects between permanent and temporary seeds are similar. There is a risk of erectile dysfunction, of inflammation of the urethra (urethritis). Urethritis is typically a short-term side effect, with the issue resolving in about 3-8 weeks after treatment. In a small percentage of men, this problem could present as a long-term side effect. When using an experienced doctor, this side effect can occur in 5-15% of men treated. A small percentage of these men can experience urethral scarring or stricture. The treatment for this can sometimes lead to incontinence. This is rare, happening in 1-3% of brachytherapy patients. 5:49 Monitoring for relapse after brachytherapy. When men have a radical prostatectomy, the PSA should be 0. After radiation, the prostate is left in place and can still make low levels of PSA. Typically if the PSA goes above 1 after radiation, this is a concern. A phenomenon associated with radiation therapy is the “PSA bump” this is the result of delayed inflammation of the prostate. This can lead to PSA levels that fluctuate unpredictably. It is important to factor this in when trying to detect a recurrence with PSA after radiation. This can occur in 25-30% of men up to 3 years after radiation treatment. 7:06 Seed implants are a good option for men with Basic or High Teal, since the cure rates are higher, and have favorable side effects compared to other forms of treatment. It is important to find an experienced physician to perform the treatment. Who we are: The Prostate Cancer Research Institute (PCRI) is a 501(c)(3) not-for-profit organization that is dedicated to helping you research your treatment options. We understand that you have many questions, and we can help you find the answers that are specific to your case. All of our resources are designed by a multidisciplinary team of advocates and expert physicians, for patients. We believe that by educating yourself about the disease, you will have more productive interactions with your medical professionals and receive better-individualized care. Feel free to explore our website or call our free helpline at 1 (800) 641-7274 with any questions that you have. Our Federal Tax ID # is 95-4617875 and qualifies for maximum charitable gift deductions by individual donors. The information on the Prostate Cancer Research Institute's YouTube channel is provided with the understanding that the Institute is not engaged in rendering medical advice or recommendation. The information provided in these videos should not replace consultations with qualified health care professionals to meet your individual medical needs. #ProstateCancer #Prostate #MarkScholzMD