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CB1 receptors

‪@thepittsburghpodcast‬ #medicalmarijuanapatient CB1 receptors, also known as cannabinoid receptor 1, are a type of G-protein-coupled receptor³. They are part of the endocannabinoid system and are predominantly found in the brain and nervous system, as well as in peripheral organs and tissues⁴. CB1 receptors are recognized as the most abundant metabotropic receptor in the brain. They are found moderately to highly expressed within the cerebral cortex (cingulate gyrus, prefrontal cortex, and hippocampus), periaqueductal gray, hypothalamus, amygdala, cerebellum, and basal ganglia (globus pallidus, substantia nigra)¹. The CB1 receptor is a pre-synaptic heteroreceptor that modulates neurotransmitter release when activated in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner¹. For more detailed information, you can refer to the [Wikipedia page on CB1 receptors](^1^) or the [Harvard Health article on the endocannabinoid system](^2^). These sources provide comprehensive information about the structure, function, and role of CB1 receptors in the human body. Source: Conversation with Bing (1) CB1 Receptors | Cannabinoid Receptors | Tocris Bioscience. https://www.tocris.com/pharmacology/c.... (2) Endocannabinoid system - Wikipedia. https://en.wikipedia.org/wiki/Endocan.... (3) Cannabinoid receptor 1 - Wikipedia. https://en.wikipedia.org/wiki/Cannabi.... (4) Cannabinoid receptor 1 - Wikipedia. https://en.wikipedia.org/wiki/Cannabi.... (5) The endocannabinoid system: Essential and mysterious. https://www.health.harvard.edu/blog/t....