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𝐑𝐞𝐬𝐳𝐨𝐧 𝐋𝐲𝐦𝐩𝐡𝐚𝐭𝐢𝐜 𝐅𝐢𝐥𝐚𝐫𝐢𝐚𝐬𝐢𝐬 𝐑𝐚𝐩𝐢𝐝 𝐓𝐞𝐬𝐭 𝐊𝐢𝐭 - 𝐏𝐚𝐧𝐋𝐅 𝐑𝐚𝐩𝐢𝐝 𝐓𝐞𝐬𝐭 𝗜𝗻𝘁𝗲𝗻𝗱𝗲𝗱 𝗨𝘀𝗲 For the detection of specific IgG4 antibodies to Wuchereria bancrofti, Brugia malayi and/or Brugia timori in human serum, plasma or whole blood. It is intended to be used as professional in vitro diagnostic test for lymphatic filariasis. 𝗦𝘂𝗺𝗺𝗮𝗿𝘆 𝗮𝗻𝗱 𝗘𝘅𝗽𝗹𝗮𝗻𝗮𝘁𝗶𝗼𝗻 𝗼𝗳 𝘁𝗵𝗲 𝗧𝗲𝘀𝘁 Lymphatic filariasis is caused by three species of blood / tissue worms namely Wuchereria bancrofti, Brugia malayi and Brugia timori. One hundred and twenty million people in 83 countries of the world are infected with lymphatic filarial parasites, and it is estimated that more than 1 billion (20% of the world's population) are at risk of acquiring the infection. Ninety percent of these infections are caused by Wuchereria bancrofti (http://www.filariasis.org). The disease is transmitted by several species of mosquitoes. Infective larvae from the mosquito enter the human through the puncture wound made by the insect. The larvae then travel to lymphatic channels and lymph nodes and develop into adult worms. Infection with Wuchereria bancrofti, Brugia malayi and Brugia timori will result in symptoms and manifestations that may include recurrent fever, lymphatic damage, renal damage, adenolymphangitis, lymphoedema, hydrocoele (only in W. bancrofti infection), elephantiasis and pulmonary disease. Specific recombinant filarial genes have been expressed, purified and incorporated into an immunochromatography-based rapid test in a cassette format called PanLF Rapid for the detection of specific IgG4 to Wuchereria brancrofti, Brugia malayi and/or Brugia timori. PanLF Rapid offers many advantages which include: • usage of whole blood or serum/ plasma as sample • results in 15-25 minutes • sample collected any time of the day can be used • simple to perform • no special equipment is needed • results are easy to interpret • minimal sample volume (35 µl for whole blood or serum/ plasma)