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This VETgirl online veterinary CE video demonstrates how to perform a thoracocentesis in a dyspneic cat. By using a TFAST ultrasound, one can rapidly identify the presence of pleural effusion. Once the presence of pleural effusion has been detected, a diagnostic and therapeutic thoracocentesis should be performed. A thoracocentesis is often life-saving, and should be performed immediately in any dyspneic patient that is suspected of having pleural effusion. The thoracocentesis should be performed cranial to the rib, as the blood vessels and nerves lie caudal to the rib (“hiding” behind the rib). Thoracocentesis should be performed at the 7th to 9th intercostal space (ICS) to avoid the heart (3-5th ICS) or liver (caudal to the 9th ICS). The patient should be shaved, scrubbed, and prepared for sterile technique. The use of a 3-way stopcock, extension tubing, an appropriately sized needle or catheter, and syringe should be used to collect air or fluid. Appropriate sterile collection tubes should be available for sample collection for cytology and/or culture purposes. For more information, go to www.vetgirlontherun.com. DISCLAIMER: Please note that this content has been made available for informational and educational purposes only. VETgirl, LLC. makes no representation or warranties regarding the accuracy, applicability, fitness, or completeness of this content. This content is not intended to be a substitute for professional advice, diagnosis, or treatment. Do not delay treatment based on this content, and when in doubt, seek veterinary professional advice.